So beware of massive spoilers.
The iconic opening kill this time is my goddess the glorious Samara Weaving looking perfect in the most figure hugging semi-see through dress ever made.


The film opens with her in restaurant speaking to her date on the phone and gets lured out into the alley across the street where Ghostface jumps out at her, stabbing her in gut and chest and shoving her up against a wall before stabbing her a bunch more times in chest as she screams and spits blood. Then as she slides down wall on the brink the killer slashes her once final time with her blood spraying his mask. We then get an incredible lingering close up of her dead face staring listlessly as blood drips from her lips. Then later a show of her from stomach up slumped against wall with chest bloody. Found this cap of it.

Then she's seen in background full body slumped against wall as killer is in foreground. During the scene there is some good focus of her feet in sexy high heels as they struggle or drag against ground as she's shoved up against wall.
Later in film when police are going over things there is a very great crime scene photo of her slumped dead against wall on the board the detectives are looking over. Now I am bias of course as Samara is one of my two dream girls and great loves so her presence obviously affects me a lot more than it may most but for me this is about the best and sexiest death scene ever in a scream film and most any film really, being absolutely incredible and Samara's performance and earth shattering beauty are pure perfection. This will go down in the hall of fame to be sure.
The second kill comes when Devyn Nekoda who plays Anika... one of the leads new friends... is killed when Ghostface brutally assaults the group in their apartment. First Anika is shoved down and choked some in struggle before she's stabbed in belly, the knife is twisted in wound and sliced slowly up quite a bit. She survives this as she and others lock themselves in room and then try and escape to another apartment over a ladder put between the windows. Anika is last to crawl over and Ghostface grabs onto ladder and shakes it till she falls off, plummets a few stories and smashes her head on a dumpser. We see close up of her face with one half kind of fucked up and squished gorily.
The final female kill is lady Ghostface Liana Liberato who earlier in the film faked her own death with her partner when he "attacked" her while shes scantly clad in her bedroom. The attack is not seen obviously but he bursts out of the room and shoves her bloody "body" at her friends causing it crash into them and knock them off their feet as Liana rolls off of them on her back, staring widely.
Her actual death comes when clad in ghostface robe with mask off when leading heroine Melissa Barrera gets the drop on her with a gun and shoots her right in the center of her forehead, splattering blood out the back of her head as she pulls a shocked face and drops backwards dead, her body not shown after.